Top 35 Healthcare Startups - June 2025 Update

 

Top 35 Healthcare Startups - June 2025 Update

Introduction

The healthcare startup landscape in 2025 represents one of the most dynamic and transformative periods in medical innovation history. As we reach the midpoint of 2025, the convergence of artificial intelligence, personalized medicine, and digital-first healthcare delivery has fundamentally reshaped how we approach patient care, clinical operations, and health outcomes.

This year has witnessed unprecedented investment momentum, with healthcare startups securing over $15 billion in funding across the first half of 2025 alone. The sector has produced multiple new unicorns, including breakthrough AI companies like Hippocratic AI and Abridge, while established players continue to scale their operations and expand their market reach.

What sets 2025 apart is the maturation of AI-powered healthcare solutions that are moving beyond pilot programs into mainstream clinical practice. From diagnostic imaging that can detect diseases earlier than human specialists to virtual care platforms that provide 24/7 access to personalized treatment, these innovations are addressing some of healthcare's most persistent challenges: accessibility, affordability, and quality of care.

The mental health revolution continues to gain momentum, driven by increasing workplace awareness and the growing recognition of mental wellness as fundamental to overall health. Meanwhile, value-based care models are reshaping how healthcare services are delivered and paid for, with startups leading the charge in outcome-driven approaches.

Perhaps most significantly, 2025 has seen healthcare startups tackle the industry's workforce crisis head-on, with innovative platforms that connect healthcare professionals with flexible work opportunities while helping facilities optimize their staffing needs.

The following list represents the most impactful healthcare startups currently shaping the future of medicine, ranked by their funding levels, market influence, and potential to transform patient care in the years ahead.

Newly Emerged Unicorns & High-Value Startups (2025)

1. Abridge

• Location: Pittsburgh, Pennsylvania
• Valuation: $2.8 billion (2025)
• Focus: AI-powered medical conversation technology
• What they do: Transforms clinical conversations into structured documentation using AI, helping healthcare providers save time on documentation while improving patient care.

2. Hippocratic AI

• Location: Palo Alto, California
• Valuation: $1+ billion (January 2025 unicorn)
• Focus: AI-powered healthcare assistants
• What they do: Develops AI agents specifically designed for healthcare applications, focusing on patient safety and clinical workflows.

3. Peregrine

• Location: Palo Alto, California
• Valuation: $2.5 billion (2025)
• Focus: Medtech and AI diagnostics
• What they do: Advanced medical technology solutions leveraging AI for improved diagnostic accuracy and patient outcomes.

Established Leaders with Recent Updates

4. Hinge Health

• Location: San Francisco, California
• Funding: Series E, $1 billion+
• Focus: Digital musculoskeletal care
• What they do: Provides digital physical therapy and chronic pain management through personalized exercise programs and coaching.

5. Ro (including Modern Fertility)

• Location: New York, New York
• Total Funding: $1+ billion
• Focus: Direct-to-consumer healthcare
• What they do: Telehealth platform offering treatments for various conditions including fertility, mental health, and chronic diseases.

6. Lyra Health

• Location: Burlingame, California
• Total Funding: $906 million
• Focus: Mental health benefits platform
• What they do: Provides comprehensive mental health benefits for employers, connecting employees with therapists and digital mental health tools.

7. Devoted Health

• Location: Waltham, Massachusetts
• Total Funding: ~$2.25 billion
• Focus: Medicare Advantage
• What they do: Technology-enabled Medicare Advantage plans focused on improving outcomes for seniors through integrated care management.

8. Radiology Partners

• Location: El Segundo, California
• Total Funding: ~$2.06 billion
• Focus: Radiology services
• What they do: Physician-led radiology practice providing imaging services with AI-enhanced diagnostics and workflow optimization.

9. Carbon Health

• Location: San Francisco, California
• Funding: Series D, $622.5 million
• Focus: Primary care and urgent care
• What they do: Omnichannel healthcare platform combining in-person and virtual care with same-day appointments and integrated health records.

10. Medable

• Location: Palo Alto, California
• Funding: Series D, $506.6 million
• Focus: Clinical trial technology
• What they do: Decentralized clinical trial platform that streamlines research processes for pharmaceutical companies and improves patient participation.

High-Growth Startups and Emerging Leaders

11. Komodo Health

• Location: San Francisco, California
• Funding: $514 million
• Focus: Healthcare data analytics
• What they do: Real-world data platform that provides insights into patient journeys and treatment outcomes using comprehensive healthcare data.

12. Virta Health

• Location: San Francisco, California
• Funding: Series E, $373 million
• Focus: Type 2 diabetes reversal
• What they do: Provides online specialty medical clinic for reversing type 2 diabetes through personalized nutrition and continuous care.

13. Spring Health

• Location: New York, New York
• Funding: $366.5 million
• Focus: Mental health care
• What they do: Precision mental healthcare platform that uses AI to match patients with personalized treatment options and providers.

14. K Health

• Location: New York, New York
• Funding: $330.3 million
• Focus: AI-powered primary care
• What they do: Affordable primary care platform using AI to provide 24/7 healthcare access and personalized treatment recommendations.

15. Flatiron Health (Acquired by Roche)

• Location: New York, New York
• Funding: Series D, $324.9 million
• Focus: Oncology data platform
• What they do: Real-world evidence platform for cancer care, helping oncologists make data-driven treatment decisions.

16. Headspace Health

• Location: Santa Monica, California
• Funding: $320.9 million
• Focus: Mental health and meditation
• What they do: Digital mental health platform offering meditation, mindfulness, and mental health support tools for consumers and enterprises.

17. Collective Health

• Location: San Mateo, California
• Funding: Series F, $719 million
• Focus: Employee health benefits
• What they do: Technology platform that helps employers design and manage custom health benefit plans with integrated care management.

18. Paige

• Location: New York, New York
• Funding: Series C, $220 million
• Focus: AI-powered pathology
• What they do: AI platform for pathologists that enhances diagnostic accuracy and efficiency in cancer detection and treatment planning.

19. SonderMind

• Location: Denver, Colorado
• Funding: Series C, $183 million
• Focus: Behavioral health platform
• What they do: Technology-enabled behavioral health platform connecting patients with therapists and providing integrated mental health solutions.

20. NexHealth

• Location: San Francisco, California
• Funding: Series C, $177.2 million
• Focus: Healthcare infrastructure
• What they do: Patient experience platform that synchronizes patient data across healthcare systems and enables seamless scheduling and communication.

21. Trusted Health

• Location: San Francisco, California
• Funding: Series C, $174.5 million
• Focus: Nursing workforce platform
• What they do: Marketplace connecting nurses with flexible work opportunities and healthcare facilities with qualified nursing staff.

22. IntelyCare

• Location: Quincy, Massachusetts
• Funding: Series C, $170.8 Million
• Focus: Nursing workforce technology
• What they do: Mobile app platform enabling nurses to find flexible work opportunities while helping healthcare facilities optimize staffing.

23. Modern Health

• Location: San Francisco, California
• Funding: $170+ million
• Focus: Employee mental health
• What they do: Comprehensive mental health platform for employers, offering therapy, coaching, and digital mental health resources.

24. Oura

• Location: Oulu, Finland
• Funding: $148.3 million
• Focus: Wearable health technology
• What they do: Smart ring technology that tracks sleep, activity, and recovery metrics to provide personalized health insights.

25. Tebra (PatientPop + Kareo merger)

• Location: Corona Del Mar, California
• Funding: Series B, $137 million
• Focus: Practice management software
• What they do: Comprehensive platform for independent healthcare practices covering patient engagement, billing, and practice growth.

26. Pivot (formerly Carrot)

• Location: California, United States
• Funding: $70 million
• Focus: Tobacco cessation
• What they do: Digital behavioral health platform focused on helping users quit smoking through personalized coaching and support.

27. Levels

• Location: New York, New York
• Funding: Series A, $57 million
• Focus: Metabolic health
• What they do: Continuous glucose monitoring platform for non-diabetics to optimize metabolic health through real-time data insights.

28. Vori Health

• Location: San Francisco, California
• Funding: Series A, $56.3 million
• Focus: Musculoskeletal care
• What they do: Comprehensive musculoskeletal healthcare platform providing physical therapy, imaging, and specialized care coordination.

29. Meru Health

• Location: San Mateo, California
• Funding: $53.3 million
• Focus: Mental health treatment
• What they do: App-based mental health treatment platform offering 12-week programs combining therapy, psychiatry, and digital tools.

30. Somatus

• Location: McLean, Virginia
• Funding: Series E, $465.1 million
• Focus: Kidney care
• What they do: Integrated kidney care platform providing comprehensive care management for patients with chronic kidney disease.

31. Wellframe

• Location: Boston, Massachusetts
• Funding: Series C, $45.2 million
• Focus: Care management platform
• What they do: Digital care management platform that helps health plans improve member engagement and health outcomes.

32. Parsley Health

• Location: New York, New York
• Funding: Series B, $36 million
• Focus: Functional medicine
• What they do: Membership-based primary care practice focusing on root-cause medicine and personalized treatment plans.

33. Intellect

• Location: Singapore
• Funding: $32.7 million
• Focus: Asian mental health
• What they do: Mental health platform specifically designed for Asian markets, providing culturally relevant therapy and coaching services.

34. Bloom Diagnostics

• Location: Zurich, Switzerland
• Funding: Series B, $28.2 million
• Focus: At-home diagnostics
• What they do: Consumer health platform offering at-home diagnostic testing and personalized health insights.

35. Circles

• Location: Tel Aviv, Israel
• Funding: Series A, $24.5 million
• Focus: Mental health support groups
• What they do: Platform connecting people with professionally-led support groups for various mental health conditions and life challenges.

Key Trends in Healthcare Startups 2025

• AI Integration: Most successful startups are incorporating AI for diagnostics, treatment recommendations, and operational efficiency
• Mental Health Focus: Significant investment continues in mental health solutions, especially for enterprise clients
• Value-Based Care: Shift toward outcome-based healthcare models and integrated care management
• Digital-First Approach: Telehealth and remote monitoring remain central to healthcare delivery
• Workforce Solutions: Growing focus on addressing healthcare staffing challenges through technology
• Personalized Medicine: Increased emphasis on individualized treatment approaches using data analytics

Note: Funding amounts and valuations reflect the most recent available data as of June 2025. The healthcare startup landscape continues to evolve rapidly with new funding rounds and company developments.